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冠心病
高血压
心律失常
先天性心脏病
什么是代谢综合征?
代谢综合征是多种代谢成分异常聚集的病理状...
心脏病患者可以怀孕吗?
1 孕前 有机械瓣或伴发心房颤动的二尖瓣狭...
有降高血压的食物吗?
一旦得了高血压,医生就会建议病人控制...
冠心病的危险因素有哪些?
目前公认的冠心病的主要危险因素包括年龄(...

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先天性心脏病
gama H2AX位点是儿童X线暴露的生物标志

Background—A better knowledge of patient x-ray dose and the associated radiation risk in pediatric interventional cardiology is warranted in view of the extensive use of x-rays and the higher radiosensitivity of children. In the present study, {gamma}-H2AX foci were used as a biomarker for radiation-induced effects. Patient-specific dose was assessed and radiation risks were estimated according to the linear-no-threshold model, commonly used in radiation protection, and the {gamma}-H2AX foci data.

Methods and Results—In 49 pediatric patients (median age, 0.75 years) with congenital heart disease who underwent cardiac catheterization procedures, blood samples were taken before and shortly after the procedure. {gamma}-H2AX foci were determined in peripheral blood T lymphocytes. In each patient, a net increase in {gamma}-H2AX foci, representing DNA double-strand breaks induced by interventional x-rays, was observed. In addition, a patient-specific Monte Carlo simulation of the procedure was performed, resulting in individual blood, organ, and tissue doses. Plotting of {gamma}-H2AX foci versus blood dose indicated a low-dose hypersensitivity. Median effective doses calculated according to the International Commission on Radiological Protection 60 and 103 publications are 5.6 and 6.4 mSv, respectively. The lifetime-attributable risk of cancer mortality was calculated from the linear-no-threshold model and the {gamma}-H2AX foci data. This resulted in lifetime-attributable risk values of 1% and 4%, respectively, for the patient population under study.

Conclusions{gamma}-H2AX foci as a biomarker for DNA damage indicate that radiation risk estimates according to the linear-no-threshold hypothesis are possibly underestimates. Great care should be taken to minimize and optimize patient radiation exposure.

 
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